Hello again Rochelle!
While they cannot guarantee a specific room, you are able to make room requests with your resort reservations. And from my experience, Disney will make every attempt possible to accommodate that request.
If you're looking for a river view, Buildings 2 and 5 are closest to the boat launch. But boat service from Port Orleans sails only to Downtown Disney. If you are looking for transportation to any of the theme or water parks, you will using bus services.
My family stayed at Port Orleans French Quarter with my wheelchair-bound Mom and had a room in Building 4. We had a handicap accessible room and overlooked a beautiful garden. We were close to the transportation bus stop and Sassagoula Floatworks and Food Factory. It worked out great!
To see a list of transportation options between the resort and various Disney locales, click
here.
Continued luck with the planning! Enjoy your trip!